formulation and release characteristics of sustained release diltiazem hydrochloride tablet pdf

Formulation And Release Characteristics Of Sustained Release Diltiazem Hydrochloride Tablet Pdf

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Modified-release dosage is a mechanism that in contrast to immediate-release dosage delivers a drug with a delay after its administration delayed-release dosage or for a prolonged period of time extended-release [ER, XR, XL] dosage or to a specific target in the body targeted-release dosage. Sustained-release dosage forms are dosage forms designed to release liberate a drug at a predetermined rate in order to maintain a constant drug concentration for a specific period of time with minimum side effects.

WO1990006107A1 - Sustained release diltiazem formulation - Google Patents

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. This study is based on the QbD development of extended-release ER extruded-spheronized pellets of Meclizine HCl and its comparative pharmacokinetic evaluation with immediate-release IR pellets. HPLC-fluorescence method was developed and validated for plasma drug analysis. The C max of IR pellets

Conventional drug delivery system for treating the angina and hypertension are not much effective as the drug do not reach the site of action in appropriate amounts. Thus potent and guarded therapy of this angina and hypertension disorder using specific drug delivery system is a challenging task to the pharmaceutical professionals. Most oftenly used method of regulating the drug release is to include it in a matrix system because of their pliability, hydrophilic polymer matrices are widely used in oral controlled drug delivery to obtain a desirable drug release pattern, methodical, and broad regulatory compliance. Formulation of Nifedipine sustained release matrix tablet was prepared by the polymers blend with to get desirable drug release profile. Evaluation parameters of formulated tablets were hardness, friability, thickness, drug content uniformity weight variation, and the in vitro drug release rate pattern.

Modified-release dosage

Show all documents For first 2 h tablet was placed in 1. At specified intervals 5 ml samples were withdrawn from the dissolution medium and replaced with fresh medium to keep the volume constant. The absorbance of the sample solution was analyzed at nm for the presence of model drug, using a UV-visible spectrophotometer. Results are shown in Table 4.


The release characteristics of Diltiazem HCl from matrix tablets were determined according to the official method using a six station USP Apparatus-II at rpm .


Formulation and Evaluation of Sustained Release Matrix Tablets of Nifedipine

Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the fast disintegrating tablet of Cetirizine Hydrochloride for allergic and respiratory disorders. Hence, the present investigation was undertaken with a view to develop a fast disintegrating tablet of Cetirizine Hydrochloride which offers a new range of products having desired characteristics and intended benefits. Superdisintegrants such as Sodium Starch Glycolate were optimized.

Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. Qazi and M. Shoaib and R. Yousuf and Tanveer Mustafa Qazi and Z.

The purpose of this study was to develop a bilayer floating drug delivery system of Diltiazem Hydrochloride DTZ. Floating drug delivery systems can remain in the gastric region for several hours and therefore prolong the astric residence time of drugs and improve drug bioavailability. In this study novel bilayer formulation of floating tablet comprising drug contained core and floated outer layer was prepared.

Research Journal of Pharmacy and Technology
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5 Comments

  1. Fucsia S.

    SUSTAINED RELEASE MATRIX TABLET OF DILTIAZEM HYDROCHLORIDE IT'S FORMULATION AND EVALUATION. February ; INTERNATIONAL.

    19.05.2021 at 09:03 Reply
  2. Neri J.

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    21.05.2021 at 00:16 Reply
  3. Esfreesovna

    Tripathi , Amit Alexander , Ajazuddin.

    22.05.2021 at 23:50 Reply
  4. Honeyy86

    Formulation and evaluation of oral sustained release of Diltiazem Download full-text PDF Composition of Diltiazem hydrochloride matrix tablet. . The Infra-red studies reveal that both of the characteristics bands around and

    26.05.2021 at 07:56 Reply
  5. Delmar G.

    A commercial diltiazem hydrochloride product Dilzem SR, was used as a compared well with the reference (p < ) in terms of release characteristics.

    27.05.2021 at 16:31 Reply

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